Osteoporosis, an age-related disease of skeletal system, may occur due to
- A.
immune disorder affecting neuromuscular junction leading to fatigue
- B.
high concentration of and
- C.
decreased level of estrogen
- D.
accumulation of uric acid leading to inflammation of joints.
- Recall what osteoporosis is.
Osteoporosis is a reduction in bone mineral density, which makes bones brittle and prone to fracture.
- Recall who is commonly affected.
Generalised osteoporosis is common in the elderly, and especially in women after menopause.
- Understand the link to estrogen.
After menopause, estrogen levels in blood plasma drop significantly. Estrogen normally helps regulate osteoclasts, the cells responsible for building new bone.
- Connect low estrogen to bone loss.
When estrogen levels drop, fewer osteoclasts are produced, which results in osteoporosis.
- Eliminate the other options.
An immune disorder affecting the neuromuscular junction describes myasthenia gravis, and accumulation of uric acid causing joint inflammation describes gout — neither is the cause of osteoporosis.
Hence, the answer is Option C (decreased level of estrogen).